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医学分子生物学=Textbook of Medical Molecular Biology:英文
  • 书号:9787030629548
    作者:(美)罗伯特·F.韦弗(Robert F.Weaver)
  • 外文书名:
  • 丛书名:中国科学院教材建设专家委员会规划教材·医学英文原版改编双语教材
  • 装帧:锁线胶订
    开本:16
  • 页数:526
    字数:818000
    语种:zh-Hans
  • 出版社:科学出版社
    出版时间:2020-01-01
  • 所属分类:
  • 定价: ¥298.00元
    售价: ¥238.40元
  • 图书介质:
    纸质书

  • 购买数量: 件  可供
  • 商品总价:

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目录

  • CONTENTS
    CHAPTER 1 INTRODUCTION 1
    SECTION 1 A BRIEF HISTORY 1
    SECTION 2 MOLECULAR BIOLOGY PROMOTE MEDICINE TO THE MOLECULAR LEVEL 11
    CHAPTER 2 THE MOLECULAR NATURE OF GENES 16
    SECTION 1 THE NATURE OF GENETIC MATERIAL 16
    SECTION 2 STRUCTURE OF NUCLEIC ACIDS 21
    SECTION 3 NUCLEOSOME AND CHROMATIN ASSEMBLY 27
    SECTION 4 PHYSICAL CHEMISTRY OF NUCLEIC ACIDS 35
    CHAPTER 3 NATURE AND FUNCTION OF GENES 42
    SECTION 1 THE NATURE OF GENES 42
    SECTION 2 PROTEIN STRUCTURE AND FUNCTION 43
    SECTION 3 OVERVIEW OF GENE EXPRESSION 49
    SECTION 4 REPLICATION 57
    SECTION 5 MUTATIONS 58
    CHAPTER 4 DNA REPLICATION OF PROKARYOTES 62
    SECTION 1 GENERAL FEATURES OF PROKARYOTIC DNA REPLICATION 62
    SECTION 2 ENZYMOLOGY OF PROKARYOTIC DNA REPLICATION 69
    SECTION 3 DETAILED PROCEDURES OF PROKARYOTIC DNA REPLICATION 79
    CHAPTER 5 DNA REPLICATION OF EUKARYOTES 92
    SECTION 1 FEATURES OF EUKARYOTIC DNA REPLICATION SYSTEM 92
    SECTION 2 DETAILED PROCEDURES OF EUKARYOTIC DNA REPLICATION 103
    SECTION 3 TELOMERES AND CANCER 109
    CHAPTER 6 DNA DAMAGE AND REPAIR 111
    SECTION 1 POLYMORPHISM AND MUTATION OF GENETIC MATERIALS 111
    SECTION 2 DNA DAMAGE 112
    SECTION 3 DNA REPAIR 115
    SECTION 4 OUTCOME OF FAILURE TO REPAIR THE DAMAGED DNA 125
    CHAPTER 7 TRANSCRIPTION IN PROKARYOTES 130
    SECTION 1 COMPONENTS OF THE PROKARYOTIC TRANSCRIPTION SYSTEM 130
    SECTION 2 PROCESS OF THE PROKARYOTIC TRANSCRIPTION 133
    CHAPTER 8 REGULATION OF PROKARYOTIC TRANSCRIPTION 142
    SECTION 1 GENERAL CONSIDERATIONS ON PROTEIN–DNA INTERACTION 142
    SECTION 2 OPERONS: FINE CONTROL OF BACTERIAL TRANSCRIPTION 143
    CHAPTER 9 TRANSCRIPTION IN EUKARYOTES 164
    SECTION 1 THE EUKARYOTIC TRANSCRIPTION SYSTEM 164
    SECTION 2 PROCESS OF THE EUKARYOTIC TRANSCRIPTION 179
    CHAPTER 10 REGULATION OF TRANSCRIPTION IN EUKARYOTES 193
    SECTION 1 TRANSCRIPTIONAL ACTIVATORS: DEFINITION, CATEGORIES AND MECHANISMS 193
    SECTION 2 TRANSCRIPTIONAL REPRESSORS 212
    SECTION 3 CHROMATIN REMODELING AND TRANSCRIPTION 213
    SECTION 4 REGULATION OF TRANSCRIPTION FACTORS 223
    SECTION 5 TRANSCRIPTIONAL COACTIVATORS AND COREPRESSORS 224
    SECTION 6 SIGNALING PATHWAYS THAT REGULATE TRANSCRIPTION 230
    CHAPTER 11 POST-TRANSCRIPTIONAL EVENTS AND REGULATION 238
    SECTION 1 RNA SPLICING 238
    SECTION 2 CAPPING AND POLYADENYLATION 250
    SECTION 3 OTHER POST-TRANSCRIPTIONAL MECHANISMS OF MRNA REGULATION 260
    SECTION 4 PROCESSING EVENTS OF OTHER RNAS 269
    CHAPTER 12 TRANSLATION 276
    SECTION 1 THE CELLULAR APARATUS FOR TRANSLATION 276
    SECTION 2 INITIATION OF TRANSLATION 291
    SECTION 3 ELONGATION AND TERMINATION OF TRANSLATION 306
    CHAPTER 13 POST-TRANSLATIONAL EVENTS 323
    SECTION 1 POST-TRANSLATIONAL PROCESSING AND PROTEIN TRAFFICKING 323
    SECTION 2 SITE-SPECIFIC MODIFICATION OF PROTEINS 329
    SECTION 3 PROTEIN DEGRADATION 336
    CHAPTER 14 DNA RECOMBINATION, TRANSPOSITION & EDITING 341
    SECTION 1 THE HOMOLOGOUS RECOMBINATION 342
    SECTION 2 TRANSPOSITION 348
    SECTION 3 GENE EDITING 358
    CHAPTER 15 ONCOGENES AND TUMOR SUPPRESSOR GENES 362
    SECTION 1 ONCOGENES 362
    SECTION 2 TUMOR SUPPRESSOR GENES 372
    SECTION 3 COLLABORATIONS OF ONCOGENES AND TUMOR-SUPPRESSOR GENES IN TUMORIGENESIS 381
    CHAPTER 16 MOLECULAR CLONING METHODS 384
    SECTION 1 GENE CLONING 384
    SECTION 2 THE POLYMERASE CHAIN REACTION 396
    SECTION 3 EXPRESSING CLONED GENES 398
    CHAPTER 17 METHODS FOR STUDYING GENE FUNCTION 403
    SECTION 1 MOLECULAR SEPARATIONS 403
    SECTION 2 MOLECULAR TOOLS FOR IDENTIFYING GENES 408
    SECTION 3 ASSAYING GENE AND GENE PRODUCT INTERACTIONS 422
    SECTION 4 ANALYZING GENE FUNCTION IN THE ORGANISM 429
    CHAPTER 18 IDENTIFICATION OF DISEASE-RELATED GENES 434
    SECTION 1 A ROUTE MAP FOR IDENTIFYING DISEASE GENES 434
    SECTION 2 CHROMOSOMAL POSITIONAL CLONING OF DISEASE GENES 434
    SECTION 3 CLONING DISEASE GENES INDEPENDENTLY OF THEIR CHROMOSOMAL POSITION 443
    SECTION 4 MODELS FOR CLONING DISEASE-RELATED GENES 446
    SECTION 5 FUNCTIONAL VALIDATION OF DISEASE GENES 446
    CHAPTER 19 GENE DIAGNOSIS 448
    SECTION 1 THE CONCEPT AND CHARACTERISTICS OF GENE DIAGNOSIS 448
    SECTION 2 THE BASIC TECHNIQUES IN GENE DIAGNOSIS 449
    SECTION 3 THE MEDICAL APPLICATION OF GENE DIAGNOSIS 454
    CHAPTER 20 GENE THERAPY 459
    SECTION 1 STRATEGIES OF GENE THERAPY 459
    SECTION 2 PROCEDURES FOR GENE THERAPY 460
    SECTION 3 CLINICAL PRACTICE OF GENE THERAPY 477
    CHAPTER 21 GENOMICS AND POST-GENOMICS 484
    SECTION 1 TECHNIQUES IN GENOMIC SEQUENCING 484
    SECTION 2 STUDYING AND COMPARING GENOMIC SEQUENCES 491
    SECTION 3 TRANSCRIPTOMICS 497
    SECTION 4 PROTEOMICS 503
    SECTION 5 OTHER MOLECULAR OMICS STUDY 511
    SECTION 6 BIOINFORMATICS 512
    INDEX 517
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