本书是Pearson Prentice Hall出版社新近推出的生物工程原理与应用丛书之一，全面阐释了当前生物医学工程对重要生理组织的研究，涵盖心血管、内分泌、神经、视觉、听觉、消化和呼吸系统。主要分为四部分:定量细胞和组织生物学，包括组织块、组织动力学、形态发生、干细胞、细胞程序与调和等；细胞和组织分化，包括高通量生物学数据、细胞和组织特性、细胞和组织培养和基因转移等；工程学方法与设计，包括时间常数、缩放比例、细胞分离、生物材料成型与制作等；临床应用，包括常规方式、宿主适应和治疗性组织的生产等。
本书为读者提供了众多实用的定义、生理基础数据表格以及参考书目、索引，同时，还介绍了骨髓、骨骼肌和软骨等组织器官的组织工程。此外，还提出了组织工程研究中的一些难点和重点问题。通过阅读本书，读者会对组织工程及其细胞生物学基础有一个全面清晰的了解，也会获得更多创新的想法来进一步探索这一日益发展并且壮大的研究领域。
本书适合生物工程、生物材料、生物医学、生物化学、分子生物学以及医学等相关研究领域的高年级本科生、研究生以及教学科研人员参考使用。
样章试读
目录
- Preface
1 Introduction
1.1 Cells as Therapeutic Agents
1.2 Illustrative Examples
1.3 Cell Numbers and Growth Rates
1.4 Outline of Book
1.5 Summary
1.6 Further Reading
Part Ⅰ Quantitative Cell and Tissue Biology
2 Tissue Organization
2.1 Tissue Components
2.2 Tissue Types
2.3 Functional Subunits
2.4 Problem Decomposition
2.5 Summary
2.6 Further Reading
3 Tissue Dynamics
3.1 Dynamic States of Tissues
3.2 Homeostasis in Highly Prolific Tissues
3.3 Tissue Repair
3.4 Tissue Dynamics as Interacting Cellular-Fate Processes
3.5 Summary
3.6 Further Reading
4 Morphogenesis
4.1 Morphogenic Processes
4.2 Morphogenic Dynamics
4.3 Constraints on Morphogenesis
4.4 Summary
4.5 Further Reading
5 Stem Cells
5.1 Basic Concepts
5.2 Examples of Stem-Cell Systems
5.3 Dynamic Function of Stem-Cell Systems
5.4 Summary
5.5 Further Reading
6 Cellular-Fate Processes
6.1 Cell Differentiation
6.2 Cell Migration
6.3 Cell Division
6.4 Cell Death
6.5 Dynamics of Interacting Cellular-Fate Processes
6.6 Summary
6.7 Further Reading
7 Coordination of Cellular-Fate Processes
7.1 Soluble Signals
7.2 Cell-Extracellular Matrix Interactions
7.3 Direct Cell-Cell Contact
7.4 Response to Mechanical Stimuli
7.5 Interaction Between Signaling Mechanisms
7.6 Summary
7.7 Further Reading
Part Ⅱ Cell and Tissue Characterization
8 High-Throughput Biological Data
8.1 Basics of Molecular Biology
8.2 Genomics
8.3 Transcriptomics
8.4 Proteomics
8.5 Metabolomics
8.6 Phenomics
8.7 Era of Systems Biology
8.8 Summary
8.9 Further Reading
9 Cell and Tissue Properties
9.1 Basic Tools
9.2 Measurement of Cell Characteristics
9.3 Measurement of Tissue Characteristics
9.4 Summary
9.5 Further Reading
10 Cell and Tissue Culture
10.1 Definition and History
10.2 Types of Tissue Culture
10.3 Media
10.4 Culture Environment and Maintenance of Cells In Vitro
10.5 Characterization of Cell Function in Tissue Culture
10.6 Cryopreservation
10.7 Contaminants
10.8 Summary
10.9 Further Reading
11 Gene Transfer
11.1 Gene Transfer for Gene Therapy
11.2 Gene-Transfer Methods
11.3 Retrovirally Mediated Gene-Delivery Process
11.4 Gene Transfer for Modifying Cellular Functions
11.5 Summary
11.6 Further Reading
Part Ⅲ Engineering Methods and Design
12 Time Constants
12.1 Definition of Time Constants
12.2 Important Time Constants
12.3 Simplifying Dynamic Descriptions
12.4 Summary
12.5 Further Reading
13 Scaling up for Ex Vivo Cultivation
13.1 Using in vivo Conditions as a Guide
13.2 Key Design Challenges
13.3 Fluid Flow
13.4 Cellularity
13.5 Geometry of the Microenvironment
13.6 Multivariable Optimization
13.7 Summary
13.8 Further Reading
14 Cell Separation
14.1 Basis for Cell Separation
14.2 Characterizing Cell Separation
14.3 Practiced Cell-Separation Methods
14.4 Summary
14.5 Further Reading
15 Biomaterial Scaffolds
15.1 Biomaterial Properties
15.2 Types of Biomaterials
15.3 Summary
15.4 Further Reading
16 Tailoring Biomaterials
16.1 Tailoring Surface Chemistry and Topography
16.2 Subcellular Length Scale(<10 μm)
16.3 Cellular Scale(10-100μm)
16.4 Supracellular Scale(100μm-1cm)
16.5 Functions of Tailored Biomaterials
16.6 Summary
16.7 Further Reading
Part Ⅳ Clinical Implementation
17 Conventional Clinical Approaches to Tissue Dysfunction
17.1 Medical Therapies for Tissue Dysfunction
17.2 Surgical Therapies for Tissue Dysfunction
17.3 Temporary Support Using Extracorporeal Devices
17.4 Tissue-Engineered Therapies
17.5 Summary
17.6 Further Reading
18 Host Integration:Interacting Cell-Fate Processes
18.1 Wound-Healing Reaponse
18.2 Angiogenesis
18.3 Immune Response
18.4 Summary
18.5 Further Reading
19 Producing Tissue-Engineered Therapies
19.1 Product Characterization
19.2 Preservation
19.3 Patent Protection
19.4 Regulation of Tissue-Engineered Products
19.5 Ethical Issues
19.6 Summary
19.7 Further Reading
A Tissue-Engineering Study Problems
A.1 Part Ⅰ:Quantitative Cell and Tissue Biology
A.2 Part Ⅱ:Cell and Tissue Characterization
A.3 Part Ⅲ:Engineering Methods and Design
A.4 Part Ⅳ:Clinical Implementation
References
Index
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